Mortimer Poncz Selected Research

Platelet Factor 4

1/2022	Dose Escalation Trial of Desulfated Heparin (ODSH) in Septic Peritonitis.
11/2021	Complement mediates binding and procoagulant effects of ultralarge HIT immune complexes.
1/2020	FcRn augments induction of tissue factor activity by IgG-containing immune complexes.
1/2020	Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis.
1/2020	Recognition of PF4-VWF complexes by heparin-induced thrombocytopenia antibodies contributes to thrombus propagation.
1/2018	Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia.
3/2017	Endothelial antigen assembly leads to thrombotic complications in heparin-induced thrombocytopenia.
11/2016	Polyphosphate/platelet factor 4 complexes can mediate heparin-independent platelet activation in heparin-induced thrombocytopenia.
10/2016	The antigenic complex in HIT binds to B cells via complement and complement receptor 2 (CD21).
1/2016	Platelet Factor 4 Inhibits and Enhances HIV-1 Infection in a Concentration-Dependent Manner by Modulating Viral Attachment.

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Mortimer Poncz Research Topics

Disease

32	Thrombosis (Thrombus) 01/2022 - 02/2002
30	Thrombocytopenia (Thrombopenia) 11/2021 - 02/2002
11	Hemorrhage 11/2020 - 08/2003
9	Vascular System Injuries 05/2015 - 02/2003
8	Inflammation (Inflammations) 01/2018 - 06/2004
6	Hemophilia A (Haemophilia) 11/2020 - 12/2003
5	Sepsis (Septicemia) 01/2022 - 09/2007
5	Atherosclerosis 06/2014 - 05/2002
4	Infections 01/2018 - 01/2003
3	Neoplasms (Cancer) 01/2021 - 03/2016
3	Wounds and Injuries (Trauma) 10/2020 - 03/2016
3	Disease Susceptibility (Diathesis) 11/2011 - 08/2003
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2022 - 05/2021
2	COVID-19 01/2022 - 05/2021
2	Pneumonia (Pneumonitis) 01/2021 - 07/2010
2	Thromboembolism 01/2020 - 11/2016
2	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 12/2018 - 01/2009
2	Leukemia 01/2017 - 10/2006
1	Peritonitis 01/2022
1	Acute Erythroblastic Leukemia (Erythroleukemia) 01/2022
1	Familial Platelet Disorder with Associated Myeloid Malignancy 01/2021
1	Lung Injury 01/2021
1	Venous Thromboembolism 01/2020
1	Autoimmune Hemolytic Anemia (Cold Agglutinin Disease) 01/2020
1	Antiphospholipid Syndrome (Antiphospholipid Antibody Syndrome) 01/2020
1	Hemolysis 01/2020
1	Venous Thrombosis (Deep-Vein Thrombosis) 01/2018
1	Ischemia 08/2017
1	Acute Lung Injury 02/2017
1	Jacobsen Distal 11q Deletion Syndrome 01/2017
1	Neonatal Alloimmune Thrombocytopenia 02/2016
1	Transfusion Reaction 02/2016

Drug/Important Bio-Agent (IBA)

29	Heparin (Liquaemin)FDA LinkGeneric 01/2022 - 02/2002
23	Platelet Factor 4IBA 01/2022 - 02/2002
17	AntibodiesIBA 11/2021 - 02/2002
12	Proteins (Proteins, Gene)FDA Link 01/2022 - 08/2003
7	ChemokinesIBA 01/2020 - 06/2004
6	Immunoglobulin G (IgG)IBA 01/2022 - 02/2007
5	Antigen-Antibody Complex (Immune Complex)IBA 11/2021 - 09/2015
5	AntigensIBA 11/2021 - 02/2007
5	Thrombin FDA Link 11/2016 - 02/2007
4	Monoclonal AntibodiesIBA 01/2020 - 02/2002
4	IntegrinsIBA 01/2020 - 04/2005
4	Factor VIII (Coagulation Factor VIII)IBA 01/2019 - 12/2003
4	Hemostatics (Antihemorrhagics)IBA 01/2019 - 08/2003
4	Pharmaceutical PreparationsIBA 01/2018 - 02/2007
4	GlycosaminoglycansIBA 09/2015 - 06/2004
3	Protein Disulfide-IsomerasesIBA 01/2022 - 11/2015
3	Histones (Histone)IBA 01/2022 - 01/2014
3	Biomarkers (Surrogate Marker)IBA 05/2021 - 09/2014
3	AutoantibodiesIBA 01/2016 - 01/2005
3	ferric chlorideIBA 12/2010 - 11/2004
3	Biological ProductsIBA 09/2007 - 06/2004
2	fostamatinibIBA 01/2022 - 05/2021
2	Inflammation MediatorsIBA 01/2022 - 05/2021
2	P-SelectinIBA 01/2022 - 05/2021
2	DisulfidesIBA 01/2022 - 10/2017
2	DNA (Deoxyribonucleic Acid)IBA 01/2021 - 01/2020
2	Transcription Factors (Transcription Factor)IBA 01/2021 - 01/2017
2	Urokinase-Type Plasminogen Activator (Urokinase)FDA Link 02/2016 - 08/2003
2	Plasminogen Activators (Plasminogen Activator)IBA 02/2016 - 06/2010
2	ProdrugsIBA 02/2016 - 06/2010
2	Fibrinolytic Agents (Antithrombotic Agents)IBA 02/2016 - 08/2003
2	thiamine triphosphorate (TTP)IBA 01/2016 - 05/2015
2	von Willebrand FactorIBA 01/2016 - 05/2015
2	FibrinIBA 03/2013 - 05/2012
2	EpitopesIBA 08/2012 - 02/2002
2	Protein CIBA 09/2011 - 09/2007
2	Protamines (Protamine Sulfate)FDA Link 02/2007 - 11/2004
1	phorbolIBA 01/2022
1	Ferritins (Ferritin)IBA 05/2021
1	AcidsIBA 01/2021
1	JNK Mitogen-Activated Protein KinasesIBA 01/2021
1	RNA (Ribonucleic Acid)IBA 01/2021
1	hydroxyethyl methacrylate (HEMA)IBA 11/2020
1	Adenosine (Adenocard)FDA LinkGeneric 10/2020
1	thrombin receptor peptide SFLLRNPIBA 10/2020
1	Tirofiban (Aggrastat)FDA Link 01/2020
1	N,N-di-n-propylserotonin (NDPS)IBA 01/2020
1	polyanionsIBA 01/2020
1	Deoxyribonuclease I (Nickase)IBA 01/2020
1	Therapeutic UsesIBA 01/2019
1	serum P-component (CIt)IBA 10/2018
1	Deoxyribonucleases (DNase)FDA Link 01/2018
1	SerpinsIBA 01/2018
1	Cysteine Proteases (Cysteine Protease)IBA 01/2018
1	Serine (L-Serine)FDA Link 01/2018
1	IsomerasesIBA 10/2017
1	endoplasmic reticulum glycoprotein p72IBA 10/2017
1	Immunoglobulin FragmentsIBA 08/2017
1	Thromboplastin (Tissue Factor)IBA 08/2017
1	ThrombomodulinIBA 08/2017
1	PolyphosphatesIBA 11/2016
1	Peptide Hydrolases (Proteases)FDA Link 01/2016

Therapy/Procedure

9	Therapeutics 11/2017 - 02/2002
2	Drug Therapy (Chemotherapy) 10/2018 - 08/2007
2	Platelet Transfusion (Blood Platelet Transfusions) 11/2017 - 03/2016
2	Lasers (Laser) 03/2015 - 12/2010
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/2019
1	Radiotherapy 10/2018